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Cyclosporin

Page history last edited by PBworks 13 years ago

                              Cyclosporin is an immunosuppressive used to suppress blood cells triggering a rejected response to a transplanted organ or/and bone marrow translpant. It was the first immunosupressant that was able to supress T-cell immunity. It has been used for a majority of kidney tranplants in children all over the United States. In order to keep a suppressed rejection of one's organ, Cyclosporin must be taken regulrarly. It works quickly and used for short-term treatment of psoriasis, an immune-mediated disease which affects the skin and joint, commonly causing red scaly plaques to appear on the skin. Cyclosporin can be dangerous if used exceeding a year. Such dangers may include problems with kidney function, including kidney failure, and hypertension.

 

                                        

Biosynthesis:

 

Cylosporin, formaly known as Cyclosporin A, is a cyclic undecapeptide isoloated from a fungus originally found in Norwegian soil called Tolypocladium inflatum. Its structure is made up of 2-aminobutyric acid, D-alanine, the (2S, 3R, 4R, 6E)-2-amino-3-hydroxy-4-methyloct-6-enoic acid (C9-acid), it also consists of numerous N-methylated peptide bonds similar to the fungal depsipeptides enniatin and beauvericin.                         

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